One of the foremost Russian conductors in the great tradition of Musin and Kondrashin, Vassily Sinaisky has a distinguished career conducting and holding important positions with many of the world's leading orchestras and opera houses. Alongside his considerable experience and authentic voice in Russian repertoire, he is known for masterly interpretations of German and British repertoire both symphonic and operatic. In 2010-13 he held the position of Chief Conductor and Music Director of the Bolshoi Theatre, and in September 2020 became Music Director of the Janáček Philharmonic Ostrava.

Sinaisky holds the position of Conductor Emeritus of the BBC Philharmonic Orchestra, where memorable projects include the Shostakovich and his Heroes festival, tours to Europe and China, and many appearances at the BBC Proms. Sinaisky is also Conductor Emeritus of the Latvian National Symphony Orchestra, Honorary Conductor of the Malmö Symphony Orchestra and has previously held the positions of Music Director and Principal Conductor of the Moscow Philharmonic, Principal Guest Conductor of the Netherlands Philharmonic and Music Director of the Russian State Orchestra.

During his tenure as Chief Conductor and Music Director of the Bolshoi Theatre, Moscow, Sinaisky's many critically acclaimed productions included The Golden Cockerel directed by Kirill Serebrennikov and the Moscow premiere of Der Rosenkavalier directed by Stephen Lawless. Elsewhere, Sinaisky has conducted Iolanta and Francesca da Rimini in new productions by Stephen Lawless at Vienna’s Theater an der Wien, Boris Godunov at San Francisco Opera, Carmen and Rosenkavalier for English National Opera, and productions of Fiery Angel and Lady Macbeth of the Mtsensk District with Hans Neuenfels at the Komische Oper Berlin.

Sinaisky is a noted and influential teacher and holds the position of Professor of Conducting at the St Petersburg Conservatoire.