Yuriy Mynenko was born in Radomyshl (Ukraine). He studied singing with Yuriy Teterya at the State Music Academy Antonina Nezhdanova in Odessa, first as a baritone, then as a countertenor. Already during his studies he participated successfully in numerous singing competitions, u. a. he was the first Ukrainian singer and the first countertenor to reach the final of the BBC Cardiff Singer of the World. 

Later, his artistic work took him next to his homeland to many other European countries and the United States. So he sang at the Bolshoi Theater in Moscow, the National Theater Mannheim, the Cologne Opera, Stuttgart Opera,  Staatstheater Kassel, Theater an der Wien, as well as at the Opéra national de Paris, Opéra de Lausanne, Théâtre des Champs-Élysées Paris, Opéra Royal de Versailles, Opéra national de Lorraine Nancy, Teatro Liceu in Barcelona, Santa Fe Opera, Concertgebouw Amsterdam, Kennedy Center Washington, among others. In the season 2018/19 he debuted at Salzburg Festival.

In 2011 Yuriy Mynenko debuted at the Bolshoi Theatre in Ruslan and Lyudmila new production (conductor Vladimir Jurowski, director Dmitri Tchernyakov).