Margarita Gritskova was born in Saint Petersburg and studied piano and voice with Irina Bogatscheva at the State Conservatory of her hometown. A formative experience during her studies was her performance as Carmen under the baton of Mariss Jansons.

After completing her studies, Margarita Gritskova was engaged at the National Theatre in Weimar. Between 2012 and 2020 she has been a member of the ensemble at the Vienna State Opera.

Guest appearances have taken her to leading opera houses such as the Bayerische Staatsoper Munich, the Staatsoper Hamburg, the Deutsche Oper am Rhein, the Opera Cologne, the Zurich Opera House, the operas in Oslo and Valencia, the Opéra de Québec and to festivals such as the Salzburg Festival, Festival de Opera in Tenerife, the Rossini Festival in Pesaro and the Schleswig-Holstein Music Festival.

Highlights of her career include concerts with José Carreras in Vienna, Moscow, St. Petersburg, Innsbruck, Oviedo, Covent Garden in London and Carnegie Hall in New York. She appeared at Vienna Musikverein, Rossini Festival in Bad Wildbad, Rossini Festival in Pesaro, Russian Cultural Centre in Vienna.

She has won prizes at competitions such as the Luciano Pavarotti Competition in Modena in 2008 and the Concurso Internacional de Canto Villa de Colmenar in Spain in 2009. In 2018 Margarita Gritskova was honored as the best mezzo-soprano of the opera season 2017/18 at the Palau de les Arts Reina Sofía in Valencia.